The strategic position enjoyed by the Tenuta di Vitiano on the border of Tuscany and Umbria makes the estate easily reached from all main Umbrian and Tuscan towns. A convenient road network (highways and speedways) makes all main airports of central Italy (Florence, Rome, Pisa) easily reached.

The estate may be reached by car on the A1 highway

If you are travelling from north:
- exit A1 Arezzo
- take a left, direction Arezzo
- About 5 miles down the road follow signs for Perugia – Cortona (S.R. 71)
- Travel down the S.R. 71, direction Cortona until you hit the hamlet of Vitiano
- As you drive through town take a right to Poggio Ciliegio
- After about ½ mile take a left driving along the perimeter wall of the Tenuta di Vitiano that will be on your right
- At the end of the perimeter wall you will find the entrance to the estate on your right.

If you are travelling from south:
- exit A1 Monte San Savino
- take a right, direction Cesa and drive all the way to the town of Castiglion Fiorentino
- As you get to Catiglion Fiorentino get on the S.R. 71, direction Arezzo and drive to the hamlet of Vitiano
- Driving through town go past the church on your right and take a left to Poggio Ciliegio
- After about ½ mile take a left driving along the perimeter wall of the Tenuta di Vitiano that will be on your right
- At the end of the perimeter wall you will find the entrance to the estate on your right.

On the train (line Florence – Rome):
- Train station of Castiglion Fiorentino
- Train station of Arezzo

Both stations have a 24/7 radio texi service.